PT  - JOURNAL ARTICLE
AU  - Eva L. Dyer
AU  - Mohammad Gheshlaghi Azar
AU  - Hugo L. Fernandes
AU  - Matthew G. Perich
AU  - Stephanie Naufel
AU  - Lee Miller
AU  - Konrad P. Körding
TI  - A cryptography-based approach for movement decoding
AID  - 10.1101/080861
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 080861
4099  - http://biorxiv.org/content/early/2016/10/14/080861.short
4100  - http://biorxiv.org/content/early/2016/10/14/080861.full
AB  - Brain decoders use neural recordings to infer a user’s activity or intent. To train a decoder, we generally need infer the variables of interest (covariates) using simultaneously measured neural activity. However, there are many cases where this approach is not possible. Here we overcome this problem by introducing a fundamentally new approach for decoding called distribution alignment decoding (DAD). We use the statistics of movement, much like cryptographers use the statistics of language, to find a mapping between neural activity and motor variables. DAD learns a linear decoder which aligns the distribution of its output with the typical distribution of motor outputs by minimizing their KL-divergence. We apply our approach to a two datasets collected from the motor cortex of non-human primates (NHPs): a reaching task and an isometric force production task. We study the performance of DAD and find regimes where DAD provides comparable and in some cases, better performance than a typical supervised decoder. As DAD does not rely on the ability to record motor-related outputs, it promises to broaden the set of potential applications of brain decoding.