TY - JOUR T1 - Degenerate time-dependent network dynamics anticipate seizures in human epileptic brain JF - bioRxiv DO - 10.1101/080739 SP - 080739 AU - AdriĆ  Tauste Campo AU - Alessandro Principe AU - Miguel Ley AU - Rodrigo Rocamora AU - Gustavo Deco Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/10/13/080739.abstract N2 - Epileptic seizures are known to follow specific changes in brain dynamics. While some algorithms can nowadays robustly detect these changes, a clear understanding of the mechanism by which these alterations occur and generate seizures is still lacking. Here, we provide evidence that such changes are initiated by an alteration of physiological network state dynamics. Specifically, our analysis of long intracranial EEG recordings from a group of 10 patients identifies a critical phase of a few hours in which time-dependent network states become less variable ("degenerate") and is followed by a global functional connectivity reduction before seizure onset. This critical phase is characterized by an increased presence of high-connected network states and is shown to particularly constraint the activity of the epileptogenic zone in patients with validated good post-operative outcome. Our approach characterizes pre-seizure networks dynamics as a cascade of two sequential events providing new insights into seizure prediction and control. ER -