%0 Journal Article %A Simon Aeschbacher %A Jessica P. Selby %A John H. Willis %A Graham Coop %T Population-genomic inference of the strength and timing of selection against gene flow %D 2016 %R 10.1101/072736 %J bioRxiv %P 072736 %X The interplay of divergent selection and gene flow is key to understanding how populations adapt to local environments and how new species form. Here, we use DNA polymorphism data and genome-wide variation in recombination rate to jointly infer the strength and timing of selection, as well as the baseline level of gene flow under various demographic scenarios. We model how divergent selection leads to a negative correlation between recombination rate and genetic differentation among populations. Our theory shows that the selection density, i.e. the selection coefficient per base pair, is a key parameter underlying this relationship. We then develop a procedure for parameter estimation and apply it to two datasets from Mimulus guttatus. First, we infer a strong signal of adaptive divergence in the face of gene flow between populations growing on and off phytotoxic serpentine soils. However, the genome-wide intensity of this selection is not exceptional compared to what M. guttatus populations may typically experience when adapting to local conditions. Second, we find that selection against genome-wide introgression from the selfing sister species M. nasutus has acted to maintain a barrier between these two species over the last 250 to 500 ky. Our study provides a theoretical framework for linking genome-wide patterns of divergence and recombination with the underlying evolutionary mechanisms that drive this differentiation. %U https://www.biorxiv.org/content/biorxiv/early/2016/10/10/072736.full.pdf