%0 Journal Article %A Russell Corbett-Detig %A Emily Jacobs-Palmer %A Daniel Hartl %A Hopi Hoekstra %T Segregation distorters are not a primary source of Dobzhansky-Muller incompatibilities in house mouse hybrids %D 2014 %R 10.1101/008672 %J bioRxiv %P 008672 %X Understanding the molecular basis of species formation is an important goal in evolutionary genetics, and Dobzhansky-Muller incompatibilities are thought to be a common source of postzygotic reproductive isolation between closely related lineages. However, the evolutionary forces that lead to the accumulation of such incompatibilities between diverging taxa are poorly understood. Segregation distorters are an important source of Dobzhansky-Muller incompatibilities between Drosophila species and crop plants, but it remains unclear if the contribution of these selfish genetic elements to reproductive isolation is prevalent in other species. Here, we genotype millions of single nucleotide polymorphisms across the genome from viable sperm of first-generation hybrid male progeny in a cross between Mus musculus castaneus and M. m. domesticus, two subspecies of rodent in the earliest stages of speciation. We then search for a skew in the allele frequencies of the gametes and show that segregation distorters are not measurable contributors to observed infertility in these hybrid males, despite sufficient statistical power to detect even weak segregation distortion with our novel method. Thus, reduced hybrid male fertility in crosses between these nascent species is attributable to other evolutionary forces. %U https://www.biorxiv.org/content/biorxiv/early/2014/09/02/008672.full.pdf