TY - JOUR T1 - Genome-wide profiling of heritable and <em>de novo</em> STR variations JF - bioRxiv DO - 10.1101/077727 SP - 077727 AU - Thomas Willems AU - Dina Zielinski AU - Assaf Gordon AU - Melissa Gymrek AU - Yaniv Erlich Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/09/27/077727.abstract N2 - Short tandem repeats (STRs) are highly variable elements that play a pivotal role in multiple genetic diseases, population genetics applications, and forensic casework. However, STRs have proven problematic to genotype from high-throughput sequencing data. Here, we describe HipSTR, a novel haplotype-based method for robustly genotyping, haplotyping, and phasing STRs from whole genome sequencing data and report a genome-wide analysis and validation of de novo STR mutations. ER -