TY - JOUR T1 - A pyrethroïd-treated bed net increases host attractiveness for <em>Anopheles gambiae s.s.</em> carrying the <em>kdr</em> allele in a dual-choice olfactometer JF - bioRxiv DO - 10.1101/077552 SP - 077552 AU - Angélique Porciani AU - Malal Diop AU - Nicolas Moiroux AU - Tatiana Kadoke-Lambi AU - Anna Cohuet AU - Fabrice Chandre AU - Laurent Dormont AU - Cédric Pennetier Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/09/26/077552.abstract N2 - The use of long lasting insecticide nets (LLINs) treated with pyrethroïd is known for its major contribution in malaria control. However, LLINs are suspected to induce behavioral changes in malaria vectors, which may in turn drastically affect their efficacy against Plasmodium sp. transmission. In sub Saharan Africa, where malaria imposes the heaviest burden, the main malaria vectors are widely resistant to pyrethroïds, the insecticide family used on LLINs, which also threatens LLIN efficiency. There is therefore a crucial need for deciphering how insecticide-impregnated materials might affect the host-seeking behavior of malaria vectors in regards to insecticide resistance. In this study, we explored the impact of permethrin-impregnated net on the host attractiveness for Anopheles gambiae mosquitoes, either susceptible to insecticides, or carrying the insecticide resistance conferring allele kdr. Groups of female mosquitoes were released in a dual-choice olfactometer and their movements towards an attractive odor source (a rabbit) protected by insecticide-treated (ITN) or untreated nets (UTN) were monitored. Kdr homozygous mosquitoes, resistant to insecticides, were more attracted by a host behind an ITN than an UTN, while the presence of insecticide on the net did not affect the choice of susceptible mosquitoes. These results suggest that permethrin-impregnated net is detectable by malaria vectors and that the kdr mutation impacts their response to a LLIN protected host. We discuss the implication of these results for malaria vector control. ER -