RT Journal Article
SR Electronic
T1 The Digital Brain Bank, an open access platform for post-mortem datasets
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.06.21.449154
DO 10.1101/2021.06.21.449154
A1 Benjamin C. Tendler
A1 Taylor Hanayik
A1 Olaf Ansorge
A1 Sarah Bangerter-Christensen
A1 Gregory S. Berns
A1 Mads F. Bertelsen
A1 Katherine L. Bryant
A1 Sean Foxley
A1 Martijn P. van den Heuvel
A1 Amy F.D. Howard
A1 Istvan Huszar
A1 Alexandre A. Khrapitchev
A1 Anna Leonte
A1 Paul R. Manger
A1 Ricarda A.L. Menke
A1 Jeroen Mollink
A1 Duncan Mortimer
A1 Menuka Pallebage-Gamarallage
A1 Lea Roumazeilles
A1 Jerome Sallet
A1 Lianne H. Scholtens
A1 Connor Scott
A1 Adele Smart
A1 Martin R. Turner
A1 Chaoyue Wang
A1 Saad Jbabdi
A1 Rogier B. Mars
A1 Karla L. Miller
YR 2021
UL http://biorxiv.org/content/early/2021/09/01/2021.06.21.449154.abstract
AB Post-mortem MRI provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy, and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank), an interactive data discovery and release platform providing open access to curated, multimodal post-mortem neuroimaging datasets. Datasets span three themes - Digital Neuroanatomist: datasets for detailed neuroanatomical investigations; Digital Brain Zoo: datasets for comparative neuroanatomy; Digital Pathologist: datasets for neuropathology investigations. The first Digital Brain Bank release includes twenty one distinctive whole-brain diffusion MRI datasets for structural connectivity investigations, alongside microscopy and complementary MRI modalities. This includes one of the highest-resolution whole-brain human diffusion MRI datasets ever acquired, whole-brain diffusion MRI in fourteen non-human primate species, and one of the largest post-mortem whole-brain cohort imaging studies in neurodegeneration. Taken together, the Digital Brain Bank provides a cross-scale, cross-species investigation framework facilitating the incorporation of post-mortem data into neuroimaging studies.Competing Interest StatementThe authors have declared no competing interest.