RT Journal Article
SR Electronic
T1 A global perspective of codon usage
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 076679
DO 10.1101/076679
A1 Bohdan B. Khomtchouk
A1 Claes Wahlestedt
A1 Wolfgang Nonner
YR 2016
UL http://biorxiv.org/content/early/2016/09/21/076679.abstract
AB Diversity of codon usage across 2730 genomes from different taxa is analyzed with non-parametric methods. Usages range from near-uniform recruitment of different codons (limited by amino acid stoichiometry of encoded proteomes) to two distinct, non-uniform recruitments of nearly exclusive subsets of different codons. Intermediate usages are described as a variation from one distinct nonuniform usage to the other that involves joint, proportionate changes in the frequencies of most different codons. The two distinct non-uniform usages define two distinct genetic codes of which one employs A/U, and the other C/G, as third bases.