RT Journal Article
SR Electronic
T1 Probabilistic inference of bifurcations in single-cell data using a hierarchical mixture of factor analysers
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 076547
DO 10.1101/076547
A1 Kieran R. Campbell
A1 Christopher Yau
YR 2016
UL http://biorxiv.org/content/early/2016/09/21/076547.abstract
AB Modelling bifurcations in single-cell transcriptomics data has become an increasingly popular field of research. Several methods have been proposed to infer bifurcation structure from such data but all rely on heuristic non-probabilistic inference. Here we propose the first generative, fully probabilistic model for such inference based on a Bayesian hierarchical mixture of factor analysers. Our model exhibits competitive performance on large datasets despite implementing full MCMC sampling and its unique hierarchical prior structure enables automatic determination of genes driving the bifurcation process.