RT Journal Article SR Electronic T1 GenomeScope: Fast reference-free genome profiling from short reads JF bioRxiv FD Cold Spring Harbor Laboratory SP 075978 DO 10.1101/075978 A1 Gregory W. Vurture A1 Fritz J. Sedlazeck A1 Maria Nattestad A1 Charles J. Underwood A1 Han Fang A1 James Gurtowski A1 Michael C. Schatz YR 2016 UL http://biorxiv.org/content/early/2016/09/19/075978.abstract AB Summary GenomeScope is an open-source web tool to rapidly estimate the overall characteristics of a genome, including genome size, heterozygosity rate, and repeat content from unprocessed short reads. These features are essential for studying genome evolution, and help to choose parameters for downstream analysis. We demonstrate its accuracy on 324 simulated and 16 real datasets with a wide range in genome sizes, heterozygosity levels, and error rates.Availability and Implementation http://qb.cshl.edu/genomescope/, https://github.com/schatzlab/genomescope.gitContact mschatz@jhu.eduSupplementary information Supplementary data are available at Bioinformatics online.