RT Journal Article SR Electronic T1 N-Acyl Dopamines Induce Apoptosis in PC12 Cell Line via the O-1918-Sensitive non-CB1-non-CB2 Receptor JF bioRxiv FD Cold Spring Harbor Laboratory SP 075796 DO 10.1101/075796 A1 Mikhail G. Akimov A1 Alina M. Ashba A1 Natalia M. Gretskaya A1 Vladimir V. Bezuglov YR 2016 UL http://biorxiv.org/content/early/2016/09/19/075796.abstract AB Dopamine amides of long chain fatty acids (NADA) are a family of endogenous mammalian lipids with an unknown function; they are anti-proliferative for many cancer cell lines. The aim of this study was to identify the NADA receptor responsible for cell death induction. Using PC12 cells treated with NADA in combination with various receptor blockers, or pre-treated with the known receptor agonists to down-regulate the proposed receptor, NADA were shown to induce apoptosis. This activity was blocked only by the non-CB1-non-CB2 receptor antagonist O-1918, and by the pre-treatment with the agonists of this receptor ethanolamides of palmitic and oleic acids.