RT Journal Article SR Electronic T1 kWIP: The k-mer Weighted Inner Product, a de novo estimator of genetic similarity JF bioRxiv FD Cold Spring Harbor Laboratory SP 075481 DO 10.1101/075481 A1 Kevin D. Murray A1 Christfried Webers A1 Cheng Soon Ong A1 Justin O. Borevitz A1 Norman Warthmann YR 2016 UL http://biorxiv.org/content/early/2016/09/16/075481.abstract AB Modern techniques used in the elucidation of population genomic variation generate potentially overwhelming quantities of data. The nature and scale of this data demands the development of computationally efficient methods to determine genetic relatedness in an unbiased de novo manner. We present the k-mer Weighted Inner Product (kWIP), a novel assembly and alignment free estimator of genetic similarity. We show kWIP can recapitulate observed relationships among samples across diverse datasets and reconstruct the true relatedness between samples with simulated sequence. kWIP is licensed under the GNU GPL, and available from https://github.com/kdmurray91/kwip.