PT  - JOURNAL ARTICLE
AU  - Kevin D. Murray
AU  - Christfried Webers
AU  - Cheng Soon Ong
AU  - Justin O. Borevitz
AU  - Norman Warthmann
TI  - <kbd>kWIP</kbd>: The k-mer Weighted Inner Product, a <em>de novo</em> estimator of genetic similarity
AID  - 10.1101/075481
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 075481
4099  - http://biorxiv.org/content/early/2016/09/16/075481.short
4100  - http://biorxiv.org/content/early/2016/09/16/075481.full
AB  - Modern techniques used in the elucidation of population genomic variation generate potentially overwhelming quantities of data. The nature and scale of this data demands the development of computationally efficient methods to determine genetic relatedness in an unbiased de novo manner. We present the k-mer Weighted Inner Product (kWIP), a novel assembly and alignment free estimator of genetic similarity. We show kWIP can recapitulate observed relationships among samples across diverse datasets and reconstruct the true relatedness between samples with simulated sequence. kWIP is licensed under the GNU GPL, and available from https://github.com/kdmurray91/kwip.