PT  - JOURNAL ARTICLE
AU  - Dongil Chung
AU  - Kelly Kadlec
AU  - Jason A. Aimone
AU  - Katherine McCurry
AU  - Brooks King-Casas
AU  - Pearl H. Chiu
TI  - Risky decision-making in major depression is stable and intact
AID  - 10.1101/074690
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 074690
4099  - http://biorxiv.org/content/early/2016/09/11/074690.short
4100  - http://biorxiv.org/content/early/2016/09/11/074690.full
AB  - The clinical diagnosis and symptoms of major depressive disorder (MDD) have been closely associated with impairments in reward processing. In particular, various studies have shown blunted neural and behavioral responses to the experience of reward in depression. However, little is known about whether depression affects individuals’ valuation of potential rewards during decision-making, independent from reward experience. To address this question, we used a gambling task and a model-based analytic approach to measure two types of individual sensitivity to reward values in participants with MDD: ‘risk preference,’ indicating how objective values are subjectively perceived and ‘inverse temperature,’ determining the degree to which subjective value differences between options influences participants’ choices. On both of these measures of value sensitivity, participants with MDD were comparable to non-psychiatric controls. Both risk preference and inverse temperature were also stable over four laboratory visits and comparable between the groups at each visit. Moreover, neither value sensitivity measure varied with severity of clinical symptoms in MDD. These data suggest intact and stable value processing in MDD during risky decision-making.