PT  - JOURNAL ARTICLE
AU  - Rongxin Fang
AU  - Miao Yu
AU  - Guoqiang Li
AU  - Sora Chee
AU  - Tristin Liu
AU  - Bing Ren
TI  - MAPPING OF LONG-RANGE CHROMATIN INTERACTIONS BY PROXIMITY LIGATION ASSISTED CHIP-SEQ
AID  - 10.1101/074294
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 074294
4099  - http://biorxiv.org/content/early/2016/09/09/074294.short
4100  - http://biorxiv.org/content/early/2016/09/09/074294.full
AB  - We report a highly sensitive and cost-effective method for genome-wide identification of chromatin interactions in eukaryotic cells. Combining proximity ligation with chromatin immunoprecipitation and sequencing, the method outperforms the state of art approach in sensitivity, accuracy and ease of operation. Application of the method to mouse embryonic stem cells improves mapping of enhancer-promoter interactions.