TY - JOUR T1 - MAPPING OF LONG-RANGE CHROMATIN INTERACTIONS BY PROXIMITY LIGATION ASSISTED CHIP-SEQ JF - bioRxiv DO - 10.1101/074294 SP - 074294 AU - Rongxin Fang AU - Miao Yu AU - Guoqiang Li AU - Sora Chee AU - Tristin Liu AU - Bing Ren Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/09/09/074294.abstract N2 - We report a highly sensitive and cost-effective method for genome-wide identification of chromatin interactions in eukaryotic cells. Combining proximity ligation with chromatin immunoprecipitation and sequencing, the method outperforms the state of art approach in sensitivity, accuracy and ease of operation. Application of the method to mouse embryonic stem cells improves mapping of enhancer-promoter interactions. ER -