%0 Journal Article %A Maxwell R. Mumbach %A Adam J. Rubin %A Ryan A. Flynn %A Chao Dai %A Paul A. Khavari %A William J. Greenleaf %A Howard Y. Chang %T HiChIP: Efficient and sensitive analysis of protein-directed genome architecture %D 2016 %R 10.1101/073619 %J bioRxiv %P 073619 %X Genome conformation is central to gene control but challenging to interrogate. Here we present HiChIP, a protein-centric chromatin conformation method. HiChIP improves the yield of conformation-informative reads by over 10-fold and lowers input requirement over 100-fold relative to ChIA-PET. HiChIP of cohesin reveals multi-scale genome architecture with greater signal to background than in situ Hi-C. Thus, HiChIP adds to the toolbox of 3D genome structure and regulation for diverse biomedical applications. %U https://www.biorxiv.org/content/biorxiv/early/2016/09/08/073619.full.pdf