RT Journal Article
SR Electronic
T1 Dissection of the contribution of regulation mode to the properties of feedforward and feedback and gene regulatory motifs
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 065698
DO 10.1101/065698
A1 Bharat Ravi Iyengar
A1 Beena Pillai
A1 K.V. Venkatesh
A1 Chetan J Gadgil
YR 2016
UL http://biorxiv.org/content/early/2016/09/06/065698.abstract
AB A framework enabling dissection of the effects of motif structure (feedback or feedforward), nature of the controller (mRNA or protein), and regulation mode (transcriptional, post-transcriptional or translational) on the response to a step change in the input is presented. We have used a common model for gene expression and a common parameter set. Both structures have an activating input and repressing regulatory effect. The effect of global parameter variation on steady-state gain, overshoot, peak time, and peak duration was studied. Protein mediated motifs showed higher degree of adaptation. RNA mediated motifs had a lower tendency to exhibit peaks. For both motif structures, overshoot correlated negatively with peak time. Peak duration is a concave function of peak time for all motifs.HighlightsA common modelling framework was used to compare the properties of incoherent feedforward and negative feedback motifs.Protein mediated motifs show a higher degree of adaptation.Peaking tendency is primarily dependent on nature of regulator.Overshoot decreases with peak time whereas peak duration is a concave function of peak time.Protein mediated feedbacks show a bimodal distribution of peak duration.