RT Journal Article SR Electronic T1 Impact of type 2 diabetes on cardiorespiratory function and exercise performance JF bioRxiv FD Cold Spring Harbor Laboratory SP 073205 DO 10.1101/073205 A1 Joanie Caron A1 Gregory R. duManoir A1 Lawrence Labrecque A1 Audrey Chouinard A1 Annie Ferland A1 Paul Poirier A1 Sylvie Legault A1 Patrice Brassard YR 2016 UL http://biorxiv.org/content/early/2016/09/05/073205.abstract AB The aim of this study was to examine the impact of well-controlled uncomplicated type 2 diabetes (T2D) on exercise performance. Six obese sedentary men with T2D and 7 control participants without diabetes matched for age, sex and body mass index were recruited. Anthropometric characteristics, blood samples, resting cardiac and pulmonary functions and maximal oxygen uptake (VO2max) and ventilatory threshold were measured on a first visit. On the four subsequent visits, participants performed step transitions (6 min) of moderate-intensity exercise on an upright cycle ergometer from unloaded pedaling to 80 % of ventilatory threshold. VO2 (τVO2) and HR (τHR) kinetics were characterized with a mono-exponential model. VO2max (27.8±4.0 vs. 27.5±5.3 ml kg-1 min-1; p=0.95), τVO2 (43±6 vs. 43±10 s; p=0.73) and τHR (42±17 vs. 43±13 s; p=0.94) were similar between diabetics and controls respectively. The remaining variables were also similar between groups. These results suggest that well-controlled T2D is not associated with a reduction in VO2max or slower τVO2 and τHR.