@article {Caron073205, author = {Joanie Caron and Gregory R. duManoir and Lawrence Labrecque and Audrey Chouinard and Annie Ferland and Paul Poirier and Sylvie Legault and Patrice Brassard}, title = {Impact of type 2 diabetes on cardiorespiratory function and exercise performance}, elocation-id = {073205}, year = {2016}, doi = {10.1101/073205}, publisher = {Cold Spring Harbor Laboratory}, abstract = {The aim of this study was to examine the impact of well-controlled uncomplicated type 2 diabetes (T2D) on exercise performance. Six obese sedentary men with T2D and 7 control participants without diabetes matched for age, sex and body mass index were recruited. Anthropometric characteristics, blood samples, resting cardiac and pulmonary functions and maximal oxygen uptake (VO2max) and ventilatory threshold were measured on a first visit. On the four subsequent visits, participants performed step transitions (6 min) of moderate-intensity exercise on an upright cycle ergometer from unloaded pedaling to 80 \% of ventilatory threshold. VO2 (τVO2) and HR (τHR) kinetics were characterized with a mono-exponential model. VO2max (27.8{\textpm}4.0 vs. 27.5{\textpm}5.3 ml kg-1 min-1; p=0.95), τVO2 (43{\textpm}6 vs. 43{\textpm}10 s; p=0.73) and τHR (42{\textpm}17 vs. 43{\textpm}13 s; p=0.94) were similar between diabetics and controls respectively. The remaining variables were also similar between groups. These results suggest that well-controlled T2D is not associated with a reduction in VO2max or slower τVO2 and τHR.}, URL = {https://www.biorxiv.org/content/early/2016/09/05/073205}, eprint = {https://www.biorxiv.org/content/early/2016/09/05/073205.full.pdf}, journal = {bioRxiv} }