RT Journal Article
SR Electronic
T1 Specific excitatory connectivity for feature integration in mouse primary visual cortex
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 072595
DO 10.1101/072595
A1 Dylan R Muir
A1 Patricia Molina-Luna
A1 Morgane M Roth
A1 Fritjof Helmchen
A1 Bjöern Kampa
YR 2016
UL http://biorxiv.org/content/early/2016/09/05/072595.abstract
AB In mouse primary visual cortex (V1), local excitatory connections are more prevalent, stronger and larger between neurons that share similar functional response features. However, the extent to which rules for local cortical connection specificity shape visual responses, as well as full details relating structure and function both remain unknown. We considered whether complex responses to plaid stimuli in mouse V1 could be explained by one of two alternative connectivity schemes: whether local connections are aligned with simple feedforward visual properties, or whether local connections group across feedforward visual properties. Using a combined experimental and computational approach, we found that responses to plaid stimuli in mouse V1 were best explained by a connectivity scheme which binds multiple feedforward visual properties. Our results show that feature binding can occur through a recurrent mechanism not requiring feedforward convergence; such a mechanism is consistent with visual responses in mouse V1.