%0 Journal Article %A Y-h. Taguchi %T microRNA-mRNA interaction identification in Wilms tumor using principal component analysis based unsupervised feature extraction %D 2016 %R 10.1101/059295 %J bioRxiv %P 059295 %X Wilms tumor is one of lethal child renal cancers, for which no known disease causing mechanisms exist. In this paper, we tried to identify possible disease causing microRNA(miRNA)-mRNA pairs (interactions) by analyzing (partially matched) miRNA/mRNA gene expression profiles with the recently proposed principal component analysis based unsupervised feature extraction. It successfully identified multiple miRNA-mRNA pairs whose biological natures are convincing. Correlation coefficients between miRNA and mRNA expression in matched parts of profiles turned out to be significantly negative. Constructed miRNA-mRNA network will be a key to understand Wilms tumor causing mechanisms. %U https://www.biorxiv.org/content/biorxiv/early/2016/08/30/059295.full.pdf