TY - JOUR T1 - Astrocytes locally translate transcripts in their peripheral processes JF - bioRxiv DO - 10.1101/071795 SP - 071795 AU - Kristina Sakers AU - Allison M. Lake AU - Rohan Khazanchi AU - Rebecca Ouwenga AU - Michael J. Vasek AU - Adish Dani AU - Joseph D. Dougherty Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/08/29/071795.abstract N2 - Local translation in neuronal processes is key to the alteration of synaptic strength that contributes to long term potentiation and potentially learning and memory. Here, we present evidence that astrocytes also have ribosomes in their peripheral and perisynaptic processes, that new protein synthesis is detectable in the astrocyte periphery, and that this localized translation is both sequence dependent and enriched for particular biological functions. Enriched transcripts include key glial regulators of synaptic refinement suggesting that local production of these proteins may support microscale alterations of adjacent synapses.One Sentence Summary Local translation in astrocytes. ER -