RT Journal Article
SR Electronic
T1 Modulation of Electrotonic Coupling in the Inferior Olive by Inhibitory and Excitatory Inputs: Integration in the Glomerulus
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 072041
DO 10.1101/072041
A1 Jornt R. De Gruijl
A1 Piotr A. Sokol
A1 Mario Negrello
A1 Cris I. De Zeeuw
YR 2016
UL http://biorxiv.org/content/early/2016/08/29/072041.abstract
AB Dendritic spines in glomeruli of the inferior olive are coupled by gap junctions and receive both inhibitory and excitatory inputs, yet the function of this configuration remains to be elucidated. In this issue of Neuron, Lefler et al. (2014) show that the GABAergic input from the cerebellar nuclei to neurons of the inferior olive dynamically affects both their coupling and subthreshold oscillations for short periods, while Mathy et al. (2014) and Turecek et al. (2014) show that the glutamatergic input to the olivary neurons can instruct plasticity of coupled dendrites in the long-term. The data sets from all three papers can be reconciled when put together in a model of the neuropil comprising the characteristic olivary glomeruli.