RT Journal Article SR Electronic T1 Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank (N=4446) JF bioRxiv FD Cold Spring Harbor Laboratory SP 070912 DO 10.1101/070912 A1 Xueyi Shen A1 Lianne Reus A1 Mark J. Adams A1 Simon R. Cox A1 Ian J. Deary A1 David C. Liewald A1 Mark E. Bastin A1 Daniel J. Smith A1 Heather C. Whalley A1 Andrew M. McIntosh YR 2016 UL http://biorxiv.org/content/early/2016/08/22/070912.abstract AB Background Previous reports of altered grey and white matter structure in Major Depressive Disorder (MDD) have been inconsistent. Recent meta-analyses have, however, reported reduced hippocampal grey matter volume in MDD and reduced white matter integrity in several brain regions. The use of different diagnostic criteria, different scanners and imaging sequences may, however, obscure further anatomical differences.Methods In this study, we tested for differences in subcortical grey matter volume and white matter integrity between depressed individuals and controls in a large sample of subjects from the first data release of the UK Biobank imaging study of 4446 individuals, which used consistent diagnostic criteria at a single assessment centre, with a single MRI scanner and protocol.Results Whilst we found no significant differences in subcortical volumes, we report significant reductions in depressed individuals versus controls in global white matter integrity, as measured by fractional anisotropy (FA) (β = -0.187, p = 0.017). We also report reductions in FA in association/commissural fibres (β = -0.184, p = 0.019) and thalamic radiations (β = -0.175, p = 0.027). Examining tracts individually, we report tract-specific FA reductions in the left superior longitudinal fasciculus (β = -0.218, pcorrected = 0.012) and superior thalamic radiation (β = -0.258, pcorrected = 0.010) in subjects with depression.Conclusions Our findings highlight the need for further large adequately-powered studies of depression and provide further evidence for disrupted white matter integrity in the disorder. Future studies would focus on exploring the typical neuro-phenotype in homogenous subgroups of depression.