RT Journal Article
SR Electronic
T1 Intrinsic functional connectivity resembles cortical architecture at various levels of isoflurane anesthesia
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 070524
DO 10.1101/070524
A1 Felix Fischer
A1 Florian Pieper
A1 Edgar Galindo-Leon
A1 Gerhard Engler
A1 Claus C. Hilgetag
A1 Andreas K. Engel
YR 2016
UL http://biorxiv.org/content/early/2016/08/21/070524.abstract
AB Cortical activity patterns change in different depths of general anesthesia. Here we investigate the associated network level changes of functional connectivity. We recorded ongoing electrocorticographic (ECoG) activity from the ferret temporo-parieto-occipital cortex under various levels of isoflurane and determined the functional connectivity by computing amplitude envelope correlations. Through hierarchical clustering, we derived typical connectivity patterns corresponding to light, intermediate and deep anesthesia. Generally, amplitude correlation strength increased strongly with depth of anesthesia across all cortical areas and frequency bands. This was accompanied by the emergence of burstsuppression activity in the ECoG signal and a change of the spectrum of the amplitude envelope. Normalizing the functional connectivity patterns showed that the topographical structure remained similar across depths of anesthesia, resembling the functional association of the underlying cortical areas. Thus, while strength and temporal properties of amplitude co-modulation vary depending on the activity of local neural circuits, their network-level interaction pattern is presumably most strongly determined by the underlying structural connectivity.