RT Journal Article SR Electronic T1 Lighter: fast and memory-efficient error correction without counting JF bioRxiv FD Cold Spring Harbor Laboratory SP 005579 DO 10.1101/005579 A1 Li Song A1 Liliana Florea A1 Ben Langmead YR 2014 UL http://biorxiv.org/content/early/2014/08/07/005579.abstract AB Lighter is a fast, memory-efficient tool for correcting sequencing errors. Lighter avoids counting k-mers. Instead, it uses a pair of Bloom filters, one holding a sample of the input k-mers and the other holding k-mers likely to be correct. As long as the sampling fraction is adjusted in inverse proportion to the depth of sequencing, Bloom filter size can be held constant while maintaining near-constant accuracy. Lighter is parallelized, uses no secondary storage, and is both faster and more memory-efficient than competing approaches while achieving comparable accuracy.