PT  - JOURNAL ARTICLE
AU  - Li Song
AU  - Liliana Florea
AU  - Ben Langmead
TI  - Lighter: fast and memory-efficient error correction without counting
AID  - 10.1101/005579
DP  - 2014 Jan 01
TA  - bioRxiv
PG  - 005579
4099  - http://biorxiv.org/content/early/2014/08/07/005579.short
4100  - http://biorxiv.org/content/early/2014/08/07/005579.full
AB  - Lighter is a fast, memory-efficient tool for correcting sequencing errors. Lighter avoids counting k-mers. Instead, it uses a pair of Bloom filters, one holding a sample of the input k-mers and the other holding k-mers likely to be correct. As long as the sampling fraction is adjusted in inverse proportion to the depth of sequencing, Bloom filter size can be held constant while maintaining near-constant accuracy. Lighter is parallelized, uses no secondary storage, and is both faster and more memory-efficient than competing approaches while achieving comparable accuracy.