TY - JOUR T1 - Non-Mendelian inheritance of SNP markers reveals extensive chromosomal translocations in dioecious hops (<em>Humulus lupulus</em> L.) JF - bioRxiv DO - 10.1101/069849 SP - 069849 AU - Dong Zhang AU - Nicholi J. Pitra AU - Mark C. Coles AU - Edward S. Buckler AU - Paul D. Matthews Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/08/16/069849.abstract N2 - Genome-wide meiotic recombination structures, sex chromosomes, and candidate genes for sex determination were discovered among Humulus spp. by application of a novel, high-density molecular marker system: ~1.2M single nucleotide polymorphisms (SNPs) were profiled with genotyping-by-sequencing (GBS) among 4512 worldwide accessions, including 4396 cultivars and landraces and 116 wild accessions of hops. Pre-qualified GBS markers were validated by inferences on families, population structures and phylogeny. Candidate genes discovered for several traits, including sex and drought stress-resistance, demonstrate the quality and utility of GBS SNPs for genome-wide association studies (GWAS) and Fst analysis in hops. Most importantly, pseudo-testcross mappings in F1 families delineated non-random linkage of Mendelian and non-Mendelian markers: structures that are indicative of unusual meiotic events which may have driven the evolution and cultivation of hops. ER -