@article {Zhang069849, author = {Dong Zhang and Nicholi J. Pitra and Mark C. Coles and Edward S. Buckler and Paul D. Matthews}, title = {Non-Mendelian inheritance of SNP markers reveals extensive chromosomal translocations in dioecious hops (Humulus lupulus L.)}, elocation-id = {069849}, year = {2016}, doi = {10.1101/069849}, publisher = {Cold Spring Harbor Laboratory}, abstract = {Genome-wide meiotic recombination structures, sex chromosomes, and candidate genes for sex determination were discovered among Humulus spp. by application of a novel, high-density molecular marker system: ~1.2M single nucleotide polymorphisms (SNPs) were profiled with genotyping-by-sequencing (GBS) among 4512 worldwide accessions, including 4396 cultivars and landraces and 116 wild accessions of hops. Pre-qualified GBS markers were validated by inferences on families, population structures and phylogeny. Candidate genes discovered for several traits, including sex and drought stress-resistance, demonstrate the quality and utility of GBS SNPs for genome-wide association studies (GWAS) and Fst analysis in hops. Most importantly, pseudo-testcross mappings in F1 families delineated non-random linkage of Mendelian and non-Mendelian markers: structures that are indicative of unusual meiotic events which may have driven the evolution and cultivation of hops.}, URL = {https://www.biorxiv.org/content/early/2016/08/16/069849}, eprint = {https://www.biorxiv.org/content/early/2016/08/16/069849.full.pdf}, journal = {bioRxiv} }