RT Journal Article
SR Electronic
T1 Exaggerated CpH Methylation in the Autism-Affected Brain
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 069120
DO 10.1101/069120
A1 Shannon E. Ellis
A1 Simone Gupta
A1 Anna Moes
A1 Andrew B. West
A1 Dan E. Arking
YR 2016
UL http://biorxiv.org/content/early/2016/08/15/069120.abstract
AB The etiology of autism, a complex neurodevelopmental disorder, remains largely unexplained. Here, we explore the role of CpG and CpH (H=A, C, or T) methylation within autism-affected cortical brain tissue. While no individual site of methylation was significantly associated with autism after multi-test correction, methylated CpH di-nucleotides were markedly enriched in autism-affected brains (~2-fold enrichment at p <0.05 cut-off, p=0.002). These results further implicate epigenetic alterations in pathobiological mechanisms that underlie autism.