RT Journal Article
SR Electronic
T1 Reward learning deficits in Parkinson’s disease depend on depression
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 069062
DO 10.1101/069062
A1 Monique H.M. Timmer
A1 Guillaume Sescousse
A1 Marieke E. van der Schaaf
A1 Rianne A.J. Esselink
A1 Roshan Cools
YR 2016
UL http://biorxiv.org/content/early/2016/08/12/069062.abstract
AB Background Depression is one of the most common and debilitating non-motor symptoms of Parkinson’s disease (PD). The neurocognitive mechanisms underlying depression in PD are unclear and treatment is often suboptimal.Methods We investigated the role of striatal dopamine in reversal learning from reward and punishment by combining a controlled medication withdrawal procedure with functional magnetic resonance imaging (fMRI) in 22 non-depressed PD patients and 19 PD patients with past or present PD-related depression.Results PD patients with a PD-related depression (history) exhibited impaired reward versus punishment reversal learning as well as reduced reward versus punishment-related BOLD signal in the striatum (putamen) compared with non-depressed PD patients. No effects of dopaminergic medication were observed.Conclusions The present findings demonstrate that impairments in reversal learning from reward versus punishment and associated reward-related striatal signalling depend on the presence of (a history of) depression in PD.