TY - JOUR T1 - Physical model of the sequence-to-function map of proteins JF - bioRxiv DO - 10.1101/069039 SP - 069039 AU - Tsvi Tlusty AU - Albert Libchaber AU - Jean-Pierre Eckmann Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/08/12/069039.abstract N2 - We treat proteins as amorphous learning matter: A ‘gene’ encodes bonds in an ‘amino acid’ network making a ‘protein’. The gene is evolved until the network forms a shear band across the protein, which allows for long-range soft modes required for protein function. The evolution projects the high-dimensional sequence space onto a low-dimensional space of mechanical modes, in accord with the observed dimensional reduction between genotype and phenotype of proteins. Spectral analysis shows correspondence between localization around the shear band of both mechanical modes and sequence ripples. ER -