RT Journal Article
SR Electronic
T1 Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.04.19.440412
DO 10.1101/2021.04.19.440412
A1 Eva G. Álvarez
A1 Jonas Demeulemeester
A1 Clemency Jolly
A1 Daniel García-Souto
A1 Paula Otero
A1 Ana Pequeño
A1 Jorge Zamora
A1 Marta Tojo
A1 Javier Temes
A1 Adrian Baez-Ortega
A1 Bernardo Rodríguez-Martín
A1 Yilong Li
A1 Ana Oitaben
A1 Alicia L. Bruzos
A1 Mónica Martínez-Fernández
A1 Kerstin Haase
A1 Martin Santamarina
A1 Sonia Zumalave
A1 Rosanna Abal
A1 Jorge Rodríguez-Castro
A1 Aitor Rodriguez-Casanova
A1 Angel Diaz-Lagares
A1 Keiran Raine
A1 Adam P. Butler
A1 Atsuhi Ono
A1 Hiroshi Aikata
A1 Kazuaki Chayama
A1 Masaki Ueno
A1 Shinya Hayami
A1 Hiroki Yamaue
A1 Miguel G. Blanco
A1 Xavier Forns
A1 Carmen Rivas
A1 Sofía Pérez-del-Pulgar
A1 Raúl Torres-Ruiz
A1 Sandra Rodríguez Perales
A1 Urtzi Garaigorta
A1 Hidewaki Nakagawa
A1 Peter J. Campbell
A1 Peter Van Loo
A1 Jose M. C. Tubio
YR 2021
UL http://biorxiv.org/content/early/2021/04/19/2021.04.19.440412.abstract
AB Most cancers are characterized by the somatic acquisition of genomic rearrangements during tumour evolution that eventually drive the oncogenesis. There are different mutational mechanisms causing structural variation, some of which are specific to particular cancer types. Here, using multiplatform sequencing technologies, we identify and characterize a remarkable mutational mechanism in human hepatocellular carcinoma caused by Hepatitis B virus, by which DNA molecules from the virus are inserted into the tumour genome causing dramatic changes in its configuration, including non-homologous chromosomal fusions and megabase-size telomeric deletions. This aberrant mutational process, present in at least 8% of all HCC tumours, is active early during liver cancer evolution and can provide the driver rearrangements that a cancer clone requires to survive and grow.Competing Interest StatementThe authors have declared no competing interest.