TY - JOUR T1 - Exaggerated CpH Methylation in the Autism-Affected Brain JF - bioRxiv DO - 10.1101/069120 SP - 069120 AU - Shannon E. Ellis AU - Simone Gupta AU - Anna Moes AU - Andrew B. West AU - Dan E. Arking Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/08/11/069120.abstract N2 - The etiology of autism, a complex neurodevelopmental disorder, remains largely unexplained. Here, we explore the role of CpG and CpH (H=A, C, or T) methylation within autism-affected cortical brain tissue. While no individual site of methylation was significantly associated with autism after multi-test correction, methylated CpH di-nucleotides were markedly enriched in autism-affected brains (~2-fold enrichment at p <0.05 cut-off, p=0.002). These results further implicate epigenetic alterations in pathobiological mechanisms that underlie autism. ER -