@article {Ellis069120, author = {Shannon E. Ellis and Simone Gupta and Anna Moes and Andrew B. West and Dan E. Arking}, title = {Exaggerated CpH Methylation in the Autism-Affected Brain}, elocation-id = {069120}, year = {2016}, doi = {10.1101/069120}, publisher = {Cold Spring Harbor Laboratory}, abstract = {The etiology of autism, a complex neurodevelopmental disorder, remains largely unexplained. Here, we explore the role of CpG and CpH (H=A, C, or T) methylation within autism-affected cortical brain tissue. While no individual site of methylation was significantly associated with autism after multi-test correction, methylated CpH di-nucleotides were markedly enriched in autism-affected brains (~2-fold enrichment at p \<0.05 cut-off, p=0.002). These results further implicate epigenetic alterations in pathobiological mechanisms that underlie autism.}, URL = {https://www.biorxiv.org/content/early/2016/08/11/069120}, eprint = {https://www.biorxiv.org/content/early/2016/08/11/069120.full.pdf}, journal = {bioRxiv} }