RT Journal Article
SR Electronic
T1 Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 002626
DO 10.1101/002626
A1 Jonathan Rodenfels
A1 Oksana Lavrynenko
A1 Sophie Ayciriex
A1 Julio L. Sampaio
A1 Andrej Shevchenko
A1 Suzanne Eaton
YR 2014
UL http://biorxiv.org/content/early/2014/07/29/002626.abstract
AB In Drosophila larvae, growth and developmental timing are regulated by nutrition in a tightly coordinated fashion. The networks that couple these processes are far from understood. Here, we show that the intestine responds to nutrient availability by regulating production of a circulating lipoprotein-associated form of the signaling protein Hedgehog (Hh). Levels of circulating Hh tune the rates of growth and developmental timing in a coordinated fashion. Circulating Hh signals to the fat body to control larval growth.It regulates developmental timing by controlling ecdysteroid production in the prothoracic gland. Circulating Hh is especially important during starvation, when it is also required for mobilization of fat body triacylglycerol (TAG) stores. Thus, we demonstrate that Hh, previously known only for its local morphogenetic functions, also acts as a lipoprotein-associated endocrine hormone, coordinating the response of multiple tissues to nutrient availability.