RT Journal Article
SR Electronic
T1 Complex ancient genetic structure and cultural transitions in southern African populations
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 043562
DO 10.1101/043562
A1 Francesco Montinaro
A1 George BJ Busby
A1 Miguel Gonzalez-Santos
A1 Ockie Oosthuitzen
A1 Erika Oosthuizen
A1 Paolo Anagnostou
A1 Giovanni Destro-Bisol
A1 Vincenzo L Pascali
A1 Cristian Capelli
YR 2016
UL http://biorxiv.org/content/early/2016/08/02/043562.abstract
AB The characterization of the structure of southern Africa populations has been the subject of numerous genetic, medical, linguistic, archaeological and anthropological investigations. Current diversity in the subcontinent is the result of complex episodes of genetic admixture and cultural contact between the early inhabitants and the migrants that have arrived in the region over the last 2,000 years. Here we analyze 1,856 individuals from 91 populations, comprising novel and available genotype data to characterize the genetic ancestry profiles of 631 individuals from 51 southern African populations. Combining local ancestry and allele frequency analyses we identify a tripartite, ancient, Khoesan-related genetic structure, which correlates with geography, but not with linguistic affiliation or subsistence strategy. The fine mapping of these components in southern African populations reveals admixture dynamics and episodes of cultural reversion involving several Khoesan groups and highlights different mixtures of ancestral components in Bantu speakers and Coloured individuals.