PT  - JOURNAL ARTICLE
AU  - Francesco Montinaro
AU  - George BJ Busby
AU  - Miguel Gonzalez-Santos
AU  - Ockie Oosthuitzen
AU  - Erika Oosthuizen
AU  - Paolo Anagnostou
AU  - Giovanni Destro-Bisol
AU  - Vincenzo L Pascali
AU  - Cristian Capelli
TI  - Complex ancient genetic structure and cultural transitions in southern African populations
AID  - 10.1101/043562
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 043562
4099  - http://biorxiv.org/content/early/2016/08/02/043562.short
4100  - http://biorxiv.org/content/early/2016/08/02/043562.full
AB  - The characterization of the structure of southern Africa populations has been the subject of numerous genetic, medical, linguistic, archaeological and anthropological investigations. Current diversity in the subcontinent is the result of complex episodes of genetic admixture and cultural contact between the early inhabitants and the migrants that have arrived in the region over the last 2,000 years. Here we analyze 1,856 individuals from 91 populations, comprising novel and available genotype data to characterize the genetic ancestry profiles of 631 individuals from 51 southern African populations. Combining local ancestry and allele frequency analyses we identify a tripartite, ancient, Khoesan-related genetic structure, which correlates with geography, but not with linguistic affiliation or subsistence strategy. The fine mapping of these components in southern African populations reveals admixture dynamics and episodes of cultural reversion involving several Khoesan groups and highlights different mixtures of ancestral components in Bantu speakers and Coloured individuals.