PT  - JOURNAL ARTICLE
AU  - Daniel Falush
AU  - Lucy van Dorp
AU  - Daniel J Lawson
TI  - A tutorial on how (not) to over-interpret STRUCTURE/ADMIXTURE bar plots
AID  - 10.1101/066431
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 066431
4099  - http://biorxiv.org/content/early/2016/07/28/066431.short
4100  - http://biorxiv.org/content/early/2016/07/28/066431.full
AB  - Genetic clustering algorithms, implemented in popular programs such as STRUCTURE and ADMIXTURE, have been used extensively in the characterisation of individuals and populations based on genetic data. A successful example is reconstruction of the genetic history of African Americans who are a product of recent admixture between highly differentiated populations. Histories can also be reconstructed using the same procedure for groups which do not have admixture in their recent history, where recent genetic drift is strong or that deviate in other ways from the underlying inference model. Unfortunately, such histories can be misleading. We have implemented an approach (available at www.paintmychromsomes.com) to assessing the goodness of fit of the model using the ancestry “palettes” estimated by CHROMOPAINTER and apply it to both simulated and real examples. Combining these complementary analyses with additional methods that are designed to test specific hypothesis allows a richer and more robust analysis of recent demographic history based on genetic data.