TY - JOUR T1 - Stress-Induced Mutagenesis and Complex Adaptation JF - bioRxiv DO - 10.1101/007096 SP - 007096 AU - Yoav Ram AU - Lilach Hadany Y1 - 2014/01/01 UR - http://biorxiv.org/content/early/2014/07/21/007096.abstract N2 - Because mutations are mostly deleterious, mutation rates should be reduced by natural selection. However, mutations also provide the raw material for adaptation. Therefore, evolutionary theory suggests that the mutation rate must balance between adaptability – the ability to adapt – and adaptedness – the ability to remain adapted. We model an asexual population crossing a fitness valley and analyze the rate of complex adaptation with and without stress-induced mutagenesis – the increase of mutation rates in response to stress or maladaptation. We show that stress-induced mutagenesis increases the rate of complex adaptation without reducing the population mean fitness, thus breaking the evolutionary trade-off between adaptability and adaptedness. Our theoretical results support the hypothesis that stress-induced mutagenesis promotes adaptation and provide quantitative predictions of the rate of complex adaptation with different mutational strategies. ER -