TY - JOUR T1 - Genome-wide Variants of Eurasian Facial Shape Differentiation and DNA based Face Prediction JF - bioRxiv DO - 10.1101/062950 SP - 062950 AU - Lu Qiao AU - Yajun Yang AU - Pengcheng Fu AU - Sile Hu AU - Hang Zhou AU - Shouneng Peng AU - Jingze Tan AU - Yan Lu AU - Haiyi Lou AU - Dongsheng Lu AU - Sijie Wu AU - Jing Guo AU - Li Jin AU - Yaqun Guan AU - Sijia Wang AU - Shuhua Xu AU - Kun Tang Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/07/25/062950.abstract N2 - It is a long standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics. Genome-wide association analyses were conducted on a discovery panel of Uyghurs. Six significant loci were identified four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A quantitative model was developed to predict 3D faces based on 277 top GWAS SNPs. In hypothetic forensic scenarios, this model was found to significantly enhance the verification rate, suggesting a practical potential of related research. ER -