RT Journal Article
SR Electronic
T1 Y chromosome and mitochondrial DNA haplogroups across behavioural traits in children from the general population
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 064444
DO 10.1101/064444
A1 Laurence J. Howe
A1 A. Mesut Erzurumluoglu
A1 George Davey Smith
A1 Santiago Rodriguez
A1 Evie Stergiakouli
YR 2016
UL http://biorxiv.org/content/early/2016/07/18/064444.abstract
AB Objective To evaluate the association between Y chromosome and mitochondrial DNA haplogroups and a number of sexually-dimorphic behavioural and psychiatric traits.Methods The study sample included 4,211 males and 4,009 females with mitochondrial DNA haplogroups and 4,788 males with Y chromosome haplogroups who are part of the Avon Longitudinal Study of Parents and Children (ALSPAC). Different subsets of these populations were assessed using the Developmental and Well-being Assessment (DAWBA), Strengths and Difficulties Questionnaire (SDQ), SCDC (Social and Communication Disorder Checklist) and Psychotic Like Symptom Interview (PLIKSi) as measures of behavioural and psychiatric traits. Logistic regression was used to measure the association between haplogroups and the traits above.Results We found that the majority of behavioural traits in our cohort differed between males and females. However, Y chromosome and mitochondrial DNA major haplogroups were not associated with any of the variables. In addition, secondary analyses of Y chromosome and mitochondrial DNA subgroups also showed no association.Conclusion Y chromosome and mitochondrial DNA haplogroups are not associated with behavioural and psychiatric traits in a sample representative of the UK population.