TY - JOUR T1 - Assessment of single cell RNA-seq normalization methods JF - bioRxiv DO - 10.1101/064329 SP - 064329 AU - Bo Ding AU - Lina Zheng AU - Wei Wang Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/07/17/064329.abstract N2 - We have assessed the performance of seven normalization methods for single cell RNA-seq using data generated from dilution of RNA samples. Our analyses showed that methods considering spike-in ERCC RNA molecules significantly outperformed those not considering ERCCs. This work provides a guidance of selecting normalization methods to remove technical noise in single cell RNA-seq data. ER -