PT  - JOURNAL ARTICLE
AU  - Bo Ding
AU  - Lina Zheng
AU  - Wei Wang
TI  - Assessment of single cell RNA-seq normalization methods
AID  - 10.1101/064329
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 064329
4099  - http://biorxiv.org/content/early/2016/07/17/064329.short
4100  - http://biorxiv.org/content/early/2016/07/17/064329.full
AB  - We have assessed the performance of seven normalization methods for single cell RNA-seq using data generated from dilution of RNA samples. Our analyses showed that methods considering spike-in ERCC RNA molecules significantly outperformed those not considering ERCCs. This work provides a guidance of selecting normalization methods to remove technical noise in single cell RNA-seq data.