RT Journal Article
SR Electronic
T1 Detecting Genome-wide Variants of Eurasian Facial Shape Differentiation: DNA based Face Prediction Tested in Forensic Scenario
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 062950
DO 10.1101/062950
A1 Lu Qiao
A1 Yajun Yang
A1 Pengcheng Fu
A1 Sile Hu
A1 Hang Zhou
A1 Jingze Tan
A1 Yan Lu
A1 Haiyi Lou
A1 Dongsheng Lu
A1 Sijie Wu
A1 Jing Guo
A1 Shouneng Peng
A1 Li Jin
A1 Yaqun Guan
A1 Sijia Wang
A1 Shuhua Xu
A1 Kun Tang
YR 2016
UL http://biorxiv.org/content/early/2016/07/10/062950.abstract
AB It is a long standing question as which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial trait variations were analyzed based on high dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inner-landmarks to dense shape geometrics. A series of genome-wide association analyses were conducted on a discovery panel of Uyghurs. Six significant loci were identified and four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in two independent cohorts of Uyghurs or Southern Han Chinese. We further developed a quantitative model to predict 3D faces based on 277 top GWAS SNPs. In hypothetic forensic scenarios, this model was found to significantly enhance the rate of suspect verification, suggesting a practical potential of related research.