PT  - JOURNAL ARTICLE
AU  - Anna A. Drozdova
AU  - Sergei I. Mukhin
TI  - Lateral pressure profile in bent lipid membranes and mechanosensitive channels gating
AID  - 10.1101/062463
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 062463
4099  - http://biorxiv.org/content/early/2016/07/07/062463.short
4100  - http://biorxiv.org/content/early/2016/07/07/062463.full
AB  - This review describes the analytical calculation of lateral pressure profile in the hydrophobic part of the lipid bilayer with finite curvature based on previously developed microscopic model for lipid hydrocarbon chains. According to this theory the energy per unit chain is represented as energy of flexible string (Euler’s elastic beam of finite thickness) and interaction between chains is considered as an entropic repulsion. This microscopic theory allows to obtain expression for lateral pressure distribution in bent bilayer if treating a bending as a small deviation from the flat membrane conformation and using perturbation theory. Because lateral pressure distribution is related to elastic properties of lipid bilayer then the first moment of lateral pressure and the expression for bending modulus may be derived from this theoretical model. Finally one can estimate the energy difference between two various conformational states of mechanosensitive channel embedded into the bilayer with pressure profile Пt(z).