RT Journal Article SR Electronic T1 Personal Pharmacogenetic Testing Enhances Pharmacy Student Knowledge and Attitude Towards Precision Medicine JF bioRxiv FD Cold Spring Harbor Laboratory SP 052043 DO 10.1101/052043 A1 Dalga Surofchy A1 Sam S. Oh A1 Joshua Galanter A1 Pin Xiang A1 Megan Li A1 Su Guo A1 Tejal Desai A1 B. Joseph Guglielmo A1 Kathy Giacomini A1 Janel Long-Boyle A1 Alan HB Wu A1 Esteban G Burchard YR 2016 UL http://biorxiv.org/content/early/2016/06/30/052043.abstract AB Objective To evaluate if pharmacy students’ participation in personal pharmacogenetic (Pgx) testing enhances their knowledge and attitude towards precision medicine (PM).Methods First-year pharmacy students were offered personalized pharmacogenetic testing as a supplement to a required curricular pharmacogenomics course. Ninety-eight of 122 (80%) students completed pre- and post-course surveys assessing knowledge and attitudes regarding PM; 73 students also volunteered for personal pharmacogenetic testing of the following drug metabolizing enzymes (CYP2C19, CYP2D6, UGT1A1) and pharmacodynamics-relevant proteins (interleukin (IL)-28B & human lymphocyte antigen HLAB*5701).Results Using a linear mixed effects model, we observed statistically significant improvements in 100% of knowledge and 70% of attitude-related questions for students who decided to undergo personal pharmacogenetic testing.Conclusion Personal pharmacogenetic testing significantly enhances knowledge of and attitude related to precision medicine among PharmD trainees. This study demonstrates the feasibility and importance of educating future pharmacists by incorporating pharmacogenetic testing into professional school curricula.Funding statement This manuscript was funded by generous contributions from the UCSF School of Pharmacy by Dean B. Joseph Guglielmo, PharmD, and by the School of Pharmacy, Department of Bioengineering and Therapeutic Sciences Department Chairs Kathleen Giacomini, PhD, and Tejal Desai, PhD.