RT Journal Article
SR Electronic
T1 Comparative distribution of antisense-RNA regulated toxin-antitoxin systems
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 060863
DO 10.1101/060863
A1 Dorien S Coray
A1 Nicole Wheeler
A1 Jack A Heinemann
A1 Paul P Gardner
YR 2016
UL http://biorxiv.org/content/early/2016/06/27/060863.abstract
AB Toxin-antitoxin (TA) systems are gene modules that appear to be widely horizontally mobile. It has been proposed that type I TA systems, with an antisense RNA-antitoxin, are less mobile than other TAs but no direct comparisons have been made. We searched for type I, II and III toxin families on chromosomes, plasmids and phages across bacterial phyla.The distribution of type I TA systems were more narrow than most type II and III system families, though this was less true of more recently discovered families.We discuss how the function and phenotypes of type I TA systems as well as biases in our databases and discovery of these modules may account for differences in their distribution.