RT Journal Article
SR Electronic
T1 Varapp: A reactive web-application for variants filtering
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 060806
DO 10.1101/060806
A1 Julien Delafontaine
A1 Alexandre Masselot
A1 Robin Liechti
A1 Dmitry Kuznetsov
A1 Ioannis Xenarios
A1 Sylvain Pradervand
YR 2016
UL http://biorxiv.org/content/early/2016/06/27/060806.abstract
AB Summary: Varapp is an open-source web application to filter variants from large sets of exome data stored in a relational database. Varapp offers a reactive graphical user interface, very fast data pro-cessing, security and facility to save, reproduce and shareresults. Typically, a few seconds suffice to apply non-trivial filters to a set of half a million variants and extract a handful of potential clinically relevant targets. Varapp implements different scenarios for Mendelian diseases (dominant, recessive, de novo, X-linked, andcompound heterozygous), and allows searching for variants in genes or chro-mosomal regions of interest.Availability: The application is made of a Javascript front-end and a Python back-end. Its source code is hosted at https://github.com/varapp. A demo version isavailable at https://varapp-demo.vital-it.ch. The full documentation can be found at https://varapp-demo.vital-it.ch/docs.Contact: sylvain.pradervand{at}chuv.ch